Tuesday, May 03, 2005

Joint Venture

Biochemicon inters into Joint venture with Helyxzion, LLC of Madison WI.
Companies Missing Nanotech Opportunities
“We want to establish Helyxzion and its J.V. Partner BioChemicon as thought leaders and early mover in Nanotechnology.”
“We’re studying the players and finding out who’s who”.
"As nanotechnology goes from producing $13 billion in manufacturing revenues today to $292 billion in 2009, corporations that lack coordinated nanotech efforts could miss opportunities, make redundant investments in expensive equipment, duplicate efforts and lose touch with front-line business priorities. "

Nanotechnology continues to receive growing attention from venture capital investors. Government, universities/labs, and corporations are fueling the growth of nanotech research into profitable commercial applications.

“Governments, corporations and venture capitalists will spend more than $10.6 billion worldwide on nanotech R&D in 2005.”

• Leading VCs investing strategies
• How start ups, corporations & research labs are working with the Helyxzion
• Successful transfer of corporate, university, and government R&D into profitable ventures
• The public market’s appetite for nanotech
• Growth projections and market intelligence on commercialization sector opportunities
• Deal structures for harvesting intellectual property
• Spin out opportunities
• How nanotech is facilitating new technology applications
• Key strategies for partnering opportunities
• The convergence of Nano, bio and IT
• Timeline for commercialization for nanotech tools and applications
• International developments in nanotech IP, tech transfer, & licensing
• Determine the best nanotech opportunities and strategic initiatives
• Hear how and why investors have made the decision to invest in nanotech opportunities
• Nanotechnology are poised to make a dramatic impact on commercial applications
• Network and share ideas with leaders in Nanotechnology

Helyxzions consortium unites venture capitalists, private equity investors, corporate investors, institutional investors, technology transfer experts, licensing executives, university academia, government and corporate research scientists, emerging growth Nanotechnology companies, and government agencies.
Whether it is the fabric business, with Eddie Bauer’s new, stain-free pants, or the chip business, with new materials like carbon nanotubes promising instant-on computers, we believe nanotech is playing an increasingly important role across many traditional and emerging sectors.
“Helyxzions application will permeate through many different industries the way the Internet did and will create an investment mania” attracting VC firms that have yet to make their first investment in Nanotechnology.
Helyxzion highlights:
A computer search of 5,906 worldwide publications showed that in 1995, there were fewer than 200 articles mentioning “Nanotechnology.” There were fewer than 400 in both 1997 and 1998. Last year, there were more than 1,800 and there will be more than 3,000 this year.
The top U.S. universities in Nanotechnology include the Massachusetts Institute of Technology, Harvard University, Stanford University, the University of Virginia, the University of California, Berkeley, Cornell University, Rice University, Yale University, North Carolina State University, California Institute of Technology, Northwestern University and the University of California, Los Angeles.
There are four major areas for institutional investors: materials, modeling, measurement and manipulation.
Nanotechnology involves building from the atomic scale up, which opens up a range of new materials with new and exotic properties. Buck balls and carbon nanotubes are the most famous, but high manufacturing costs have prohibited wide-scale use.
More mundane materials, such as carbon black and layered silicates, are already being widely used in the auto industry, and Romeoville, Ill.-based Nanophase Technologies Corp. sells hundreds of tons of zinc oxide to BASF Inc. and Schering-Plough Inc. for use in suntan lotions.
The laws of physics change at nanometer scales, where quantum mechanics rules, which present challenges and opportunities to software developers, described in the book as “a rich landscape of unclaimed intellectual property.”
The book says that measurement devices are crucial and incorporate such technologies as atomic force microscopy and scanning tunneling microscopy. A wide range of tools will be needed to be built that can find and measure things as small as a single atom, and other tools will be needed to move them around to build the nanomachines and products of the future. This concept of “tiny twisters” has serious limitations and will do little for real Nanotechnology. Such devices can be made but they do not go to the heart of the Nano world. DNA on the other hand, as the blue printing technology of life does! DNA can be used in ways that no other “little tool” can. DNA already constructs the nanomachines of life “cells”. Custom engineered sequences of DNA will carry all the instruction needed; inserted into a host cell we will be able to make any Nano-device, just as nature dose!

Nanotechs time has come and Helyxzion is on the leading edge of this technological revolution. According to the National Science Foundation, by 2015 the annual global market for Nano-related goods and services will top one trillion US dollars, making it one of the fastest growing industries in history. Although the process of converting basic research into viable market products will be long and difficult, Helyxzions technology will shorten Research and Development time, making it indespensible to the industry.

Helyxzion: The Language of DNA
Introduction: The Genome: No way to read it?
Imagine a library that contains every book ever written. Now imagine you know your ABCs, but have no understanding of how to arrange the letters of the alphabet into any type of order that would allow you to form words. And then sentences. When you enter the library you would never find a single book that you could read because you don’t know how to read the language!
This is analogous to what the scientific world has been doing with DNA; entering the Library of Life, discovering and looking at the letters and the many shelves of books while trying to find meaning by experiment or trial and error. The concept of a language of DNA has been around for decades. Certainly, major advances in discovering the alphabet and decoding some of the words have been made over the years. But we never have fully understood the language. Until now with the discovery of the Helyxzion algorithm which fully explains DNA.
The “JUNK” mistake
There exists a theory in studies of DNA which infers that 97% of DNA sequences do not code for any protein therefore it is labeled as “JUNK”. Nonsense words in the language”. However, within these regions are introns and they do have many factions. During transcription, DNAs initial RNA transcript can be spliced in a different manner. An exon may be removed and an intron or portion of them substituted to produce an assortment of mRNAs, thereby creating different proteins from a single gene. This is an example of how introns (Junk DNA) can and are used to code or influence proteins. The amount of growing evidence in this area is overwhelming and the theory that any DNA is “JUNK” will be shown to be incorrect with the use of Helyxzion.
Languages exist because letters are created and put into a sequence which has meaning, i.e., a word. The connection between symbols and words have been established and documented millions of times. Consider the number of books that have been written versus the number of possibilities... The language is not inefficient but contains infinite possibilities. Without a defined language, none of the books would mean anything at all.
Some scientists have not accepted the conclusion that a language does exist in DNA. Because no one has been able to read the language, it must be nonsensical or useless. This objection is similar to the fallacy of the multitude of monkeys with time on their hands. Julian Huxley provides an example of how, given long enough, monkeys randomly banging on typewriters might be expected to produce the complete works of Shakespeare. But the fact is that they would not produce a single word of Shakespeare or indeed of English unless a language already existed for the monkeys' literary efforts to be compared to. The same is true of the language of DNA except the meaning here is the correspondence between DNA and the amino acids which are the building blocks of life. There is a direct connection between these amino acids and the corresponding DNA - the fact that they do correspond is simply a function of the pre-existing physics and chemistry. The language is the natural result we see in the sequences of DNA.
Is it just coincidence that only 3% of the DNA has function? Consider the number of genomes that exist. Do series of amino acids just happen to build themselves up into proteins, that will just happen to combine into viable living things? Any genome will always be useless without the chemistry to derive its meaning The fact that chemistry should happen to exist which is able to make sense of the genome and further that the chemistry should be able to create life forms from only 3% of a genome and all the rest of DNA is “JUNK” is certainly one theory. But another, more likely possibility is that we have not been able to understand the language...
Finding the language in DNA
The conventional view is that DNA has four letters; A, C, G, and T. These four letters are combined to form a total of twenty words. These words are the different amino acids that make up all the proteins needed by our bodies. True enough in a limited sense.
Let us now consider another way of viewing these letters in terms of the genetic language. Scientists use codons; a set of any three of the four nucleotides A, C, G, or T. 64 combinations are now possible. Each codon with a particular usage. Consider that each one of these 64 combinations may really be another “letter” instead of a final word. Now consider the English language only has 26 letters. With 64 letters, one can make an almost infinite numbers of words and thus an extremely complex language.
Complexity can imply taking chaotic and arbitrary things and formulating a semblance of order. In English the actual order of the letters is completely arbitrary without using the rules of spelling and grammar... If the nucleotide bases were self organizing and did not follow complex rules of language they would be completely useless as they would not arrange themselves into meaningful patterns but rather random strings unable to impart information that could be understood.

One thing is certain. The knowledge of the language of DNA is evolving over time.
We have looked at the genetic code and it is all about physics and chemistry, which are governed by laws. These laws are not arbitrary but explicit and result in a meaningful and useful language built into its very structure
Being governed by these laws, DNA can best be expressed mathematically. There is only one set of laws and thus one mathematic algorithm the can explain them. The Helyxzion algorithm does just that, and is the very basis and core of HELYXZION, the language of DNA.
Helyxzion uses the concept of 64 letters to build a language. Mathematical formulas are applied to the codon alphabet. The result is a readable language that has form and structure. The understanding of this language may allow scientists to explore and unravel the remaining 97% of DNA that is yet to be understood. Helyxzion continues to add structure to the continuously evolving Language of DNA.
By Dr. Charles Stevens


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